Endocrine Abstracts

Introduction: Graves’ and Hashimoto’s diseases are considered two extremes of the same autoimmune thyroid disease. Spontaneous conversion from hypothyroidism to hyperthyroidism is uncommon. On the other hand, Graves’ disease typically improves during pregnancy and worsens after delivery. We describe a patient with an unusual course of thyroid disease during pregnancy.Case report: An 33-year-old woman, with a two-year history of hypothyroid...

Introduction: Type 2 diabetes mellitus is a conformational disease (CD), characterised by deposition (fibrils and cytotoxic oligomers) of the human islet amyloid peptide (hIAPP). CDs have devastating effects on the sufferers and their caregivers, as well as a tremendous economic impact on families and the health system. Novel molecule candidates targeting self-assembled amyloidogenic proteins represent a potential therapeutic approach for CDs.Methods/des...

Introduction: There is scarcity of data on the recurrence and/or progression (R/P) rate in nonfunctioning pituitary adenomas (NFPAs) after surgery and the risk factors that can predict this outcome. So the aim of this study was to analyze a large series of NFPAs with a long follow-up after surgery, focusing on the evaluation of R/P rate and the risk factors associated with it.Methods: Retrospective cohort analysis of 164 patients with NFPAs from 3 differ...